About: Synergistic Activity of Colistin in Combination With Resveratrol Against Colistin-Resistant Gram-Negative Pathogens

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Synergistic Activity of Colistin in Combination With Resveratrol Against Colistin-Resistant Gram-Negative Pathogens
Creator	Cannatelli, Antonio Pallecchi, Lucia Principato, Silvia Bagattini, Maria Berisio, Rita »more»
topic	covid:15724c0c0f8675d894aa76e25c9a29f4266d0440#this
source	PMC
abstract	Objectives: In this study, we investigated the antimicrobial activity of resveratrol in combination with colistin, a last-resort agent for the treatment of severe infections caused by multidrug resistant Gram-negative pathogens. Methods: The synergistic activity and the bactericidal activity of colistin in combination with resveratrol was investigated by checkerboard assays and time-kill assays, respectively. A total of 21 strains were investigated, including 16 strains of different species (Klebsiella pneumoniae, n = 6, Escherichia coli, n = 6; Citrobacter braakii, n = 1; Stenotrophomonas malthophilia, n = 1; Enterobacter cloaceae, n = 1; Acinetobacter baumannii, n = 1) with acquired colistin resistance, three colistin-susceptible K. pneumoniae precursors, and two strains of intrinsically colistin-resistant species (Serratia marcescens, n = 1; Proteus mirabilis, n = 1). Mechanisms of acquired colistin resistance included chromosomal mutations (i.e., mgrB, pmrAB) and plasmid genes (mcr-1, mcr-1.2). Results: Resveratrol did not show any significant intrinsic antimicrobial activity. Overall, a relevant synergistic antimicrobial activity of resveratrol in combination with colistin was observed with all tested strains, except for the three colistin-susceptible K. pneumoniae strains, and for two mcr-1-positive E. coli strains. In time-kill assays, performed with 15 selected strains, the combination of colistin 2 mg/L plus resveratrol 128 mg/L was bactericidal with 11 strains, and bacteriostatic for the remaining ones. Conclusions: Resveratrol was found to potentiate colistin activity against a wide panel of colistin-resistant strains, regardless of species and resistance mechanisms, which would deserve further investigation for potential clinical applications.
has issue date	2018-08-07(xsd:dateTime)
bibo:doi	10.3389/fmicb.2018.01808
bibo:pmid	30131787
has license	cc-by
sha1sum (hex)	15724c0c0f8675d894aa76e25c9a29f4266d0440
schema:url	https://doi.org/10.3389/fmicb.2018.01808
resource representing a document's title	Synergistic Activity of Colistin in Combination With Resveratrol Against Colistin-Resistant Gram-Negative Pathogens
has PubMed Central identifier	PMC6091244
has PubMed identifier	30131787
schema:publication	Front Microbiol
resource representing a document's body	covid:15724c0c0f8675d894aa76e25c9a29f4266d0440#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/15724c0c0f8675d894aa76e25c9a29f4266d0440
is schema:about of	named entity 'NEGATIVE' named entity 'ACTIVITY' covid:arg/15724c0c0f8675d894aa76e25c9a29f4266d0440 named entity 'RESORT' named entity 'COLISTIN' »more»

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