About: Full-length genome analysis of two genetically distinct variants of porcine epidemic diarrhea virus in Thailand

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Full-length genome analysis of two genetically distinct variants of porcine epidemic diarrhea virus in Thailand
Creator	Cheun-Arom, Thaniwan Chongcharoen, Wanchai Kaewprommal, Pavita Nilubol, Dachrit Piriyapongsa, Jittima »more»
source	Elsevier; Medline; PMC
abstract	Porcine epidemic diarrhea virus (PEDV) has continued to cause sporadic outbreaks in Thailand since 2007 and a pandemic variant containing an insertion and deletion in the spike gene was responsible for outbreaks. In 2014, there were further outbreaks of the disease occurring within four months of each other. In this study, the full-length genome sequences of two genetically distinct PEDV isolates from the outbreaks were characterized. The two PEDV isolates, CBR1/2014 and EAS1/2014, were 28,039 and 28,033 nucleotides in length and showed 96.2% and 93.6% similarities at nucleotide and amino acid levels respectively. In total, we have observed 1048 nucleotide substitutions throughout the genome. Compared to EAS1/2014, CBR1/2014 has 2 insertions of 4 ((56)GENQ(59)) and 1 ((140)N) amino acid positions 56–59 and 140, and 2 deletions of 2 ((160)DG(161)) and 1 ((1199)Y) amino acid positions 160–161 and 1199. The phylogenetic analysis based on full-length genome of CBR1/2014 isolate has grouped the virus with the pandemic variants. In contrast, EAS1/2014 isolate was grouped with CV777, LZC and SM98, a classical variant. Our findings demonstrated the emergence of EAS1/2014, a classical variant which is novel to Thailand and genetically distinct from the currently circulating endemic variants. This study warrants further investigations into molecular epidemiology and genetic evolution of the PEDV in Thailand.
has issue date	2016-06-25(xsd:dateTime)
bibo:doi	10.1016/j.meegid.2016.06.046
bibo:pmid	27353184
has license	no-cc
sha1sum (hex)	1506c3c38c0d1d33d49fac456b8e1111ab606c63
schema:url	https://doi.org/10.1016/j.meegid.2016.06.046
resource representing a document's title	Full-length genome analysis of two genetically distinct variants of porcine epidemic diarrhea virus in Thailand
has PubMed Central identifier	PMC7185804
has PubMed identifier	27353184
schema:publication	Infect Genet Evol
resource representing a document's body	covid:1506c3c38c0d1d33d49fac456b8e1111ab606c63#body_text
is schema:about of	named entity 'Thailand' named entity 'study' named entity 'deletions' named entity 'pandemic' named entity '2007' »more»

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