About: Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis
Creator	Hsiao, Pei-Wen Chen, May Hsiang, • Hsiao, Ting-Feng Hsu, Ting-Wei »more»
source	Medline; PMC
abstract	TMPRSS2 is an important membrane-anchored serine protease involved in human prostate cancer progression and metastasis. A serine protease physiologically often comes together with a cognate inhibitor for execution of proteolytically biologic function; however, TMPRSS2’s cognate inhibitor is still elusive. To identify the cognate inhibitor of TMPRSS2, in this study, we applied co-immunoprecipitation and LC/MS/MS analysis and isolated hepatocyte growth factor activator inhibitors (HAIs) to be potential inhibitor candidates for TMPRSS2. Moreover, the recombinant HAI-2 proteins exhibited a better inhibitory effect on TMPRSS2 proteolytic activity than HAI-1, and recombinant HAI-2 proteins had a high affinity to form a complex with TMPRSS2. The immunofluorescence images further showed that TMPRSS2 was co-localized to HAI-2. Both KD1 and KD2 domain of HAI-2 showed comparable inhibitory effects on TMPRSS2 proteolytic activity. In addition, HAI-2 overexpression could suppress the induction effect of TMPRSS2 on pro-HGF activation, extracellular matrix degradation and prostate cancer cell invasion. We further determined that the expression levels of TMPRSS2 were inversely correlated with HAI-2 levels during prostate cancer progression. In orthotopic xenograft animal model, TMPRSS2 overexpression promoted prostate cancer metastasis, and HAI-2 overexpression efficiently blocked TMPRSS2-induced metastasis. In summary, the results together indicate that HAI-2 can function as a cognate inhibitor for TMPRSS2 in human prostate cancer cells and may serve as a potential factor to suppress TMPRSS2-mediated malignancy.
has issue date	2020-08-10(xsd:dateTime)
bibo:doi	10.1038/s41388-020-01413-w
bibo:pmid	32778768
has license	no-cc
sha1sum (hex)	140e1057f763c0cc5715486ef3da6399392a7042
schema:url	https://doi.org/10.1038/s41388-020-01413-w
resource representing a document's title	Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis
has PubMed Central identifier	PMC7416816
has PubMed identifier	32778768
schema:publication	Oncogene
resource representing a document's body	covid:140e1057f763c0cc5715486ef3da6399392a7042#body_text
is schema:about of	named entity 'TMPRSS2' named entity 'overexpression' named entity 'HAI' named entity 'inversely' named entity 'TMPRSS2' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software