About: Complement Evasion Strategies of Viruses: An Overview

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Complement Evasion Strategies of Viruses: An Overview
Creator	Agrawal, P Kumar, J Nawadkar, R Ojha, H Sahu, A
topic	covid:130c4c6c7faab2f0c0143b6f0cd0118b27c91dea#this
source	Medline; PMC
abstract	Being a major first line of immune defense, the complement system keeps a constant vigil against viruses. Its ability to recognize large panoply of viruses and virus-infected cells, and trigger the effector pathways, results in neutralization of viruses and killing of the infected cells. This selection pressure exerted by complement on viruses has made them evolve a multitude of countermeasures. These include targeting the recognition molecules for the avoidance of detection, targeting key enzymes and complexes of the complement pathways like C3 convertases and C5b-9 formation – either by encoding complement regulators or by recruiting membrane-bound and soluble host complement regulators, cleaving complement proteins by encoding protease, and inhibiting the synthesis of complement proteins. Additionally, viruses also exploit the complement system for their own benefit. For example, they use complement receptors as well as membrane regulators for cellular entry as well as their spread. Here, we provide an overview on the complement subversion mechanisms adopted by the members of various viral families including Poxviridae, Herpesviridae, Adenoviridae, Flaviviridae, Retroviridae, Picornaviridae, Astroviridae, Togaviridae, Orthomyxoviridae and Paramyxoviridae.
has issue date	2017-06-16(xsd:dateTime)
bibo:doi	10.3389/fmicb.2017.01117
bibo:pmid	28670306
has license	cc-by
sha1sum (hex)	130c4c6c7faab2f0c0143b6f0cd0118b27c91dea
schema:url	https://doi.org/10.3389/fmicb.2017.01117
resource representing a document's title	Complement Evasion Strategies of Viruses: An Overview
has PubMed Central identifier	PMC5472698
has PubMed identifier	28670306
schema:publication	Front Microbiol
resource representing a document's body	covid:130c4c6c7faab2f0c0143b6f0cd0118b27c91dea#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/130c4c6c7faab2f0c0143b6f0cd0118b27c91dea
is schema:about of	named entity 'OVERVIEW' named entity 'STRATEGIES' named entity 'COMPLEMENT' named entity 'VIRUSES' named entity 'C4BP' »more»

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