About: Mendelian resistance to human norovirus infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Mendelian resistance to human norovirus infections
Creator	Le Pendu, Jacques Kindberg, Elin Ruvoën-Clouet, Nathalie Svensson, Lennart
source	Elsevier; Medline; PMC
abstract	Abstract Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the α1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2−/−), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. Moreover, the capsid protein from distinct strains shows different HBGA specificities, suggesting a host–pathogen co-evolution driven by carbohydrate–protein interactions.
has issue date	2006-12-31(xsd:dateTime)
bibo:doi	10.1016/j.smim.2006.07.009
bibo:pmid	16973373
has license	els-covid
sha1sum (hex)	12c8e585dfce2ff58bda6b9a1ca27096aa720441
schema:url	https://doi.org/10.1016/j.smim.2006.07.009
resource representing a document's title	Mendelian resistance to human norovirus infections
has PubMed Central identifier	PMC7129677
has PubMed identifier	16973373
schema:publication	Seminars in Immunology
resource representing a document's body	covid:12c8e585dfce2ff58bda6b9a1ca27096aa720441#body_text
is schema:about of	named entity 'strains' named entity 'antigens' named entity 'norovirus' named entity 'controlled' named entity 'FUT2' »more»

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