About: Selective human enterovirus and rhinovirus inhibitors: An overview of capsid‐binding and protease‐inhibiting molecules

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About: Selective human enterovirus and rhinovirus inhibitors: An overview of capsid‐binding and protease‐inhibiting molecules Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Selective human enterovirus and rhinovirus inhibitors: An overview of capsid‐binding and protease‐inhibiting molecules
Creator	Shih, Shin-Ru Chen, Shu-Jen Hakimelahi, Gholam Liu, Hsing-Jang Shia, Kak-Shan »more»
source	Medline; PMC
abstract	The absence of effective vaccines for most viral infections highlights an urgent necessity for the design and development of effective antiviral drugs. Due to the advancement in virology since the late 1980s, several key events in the viral life cycle have been well delineated and a number of molecular targets have been validated, culminating in the emergence of many new antiviral drugs in recent years. Inhibitors against enteroviruses and rhinoviruses, responsible for about half of the human common colds, are currently under active investigation. Agents targeted at either viral protein 1 (VP1), a relatively conserved capsid structure mediating viral adsorption/uncoating process, or 3C protease, which is highly conserved among different serotypes and essential for viral replication, are of great potential to become antipicornavirus drugs. © 2004 Wiley Periodicals, Inc. Med Res Rev, 24, No. 4, 449–474, 2004
has issue date	2004-04-07(xsd:dateTime)
bibo:doi	10.1002/med.10067
bibo:pmid	15170592
has license	no-cc
sha1sum (hex)	11650b1552206bab37e5a751670a94aa3c38137c
schema:url	https://doi.org/10.1002/med.10067
resource representing a document's title	Selective human enterovirus and rhinovirus inhibitors: An overview of capsid‐binding and protease‐inhibiting molecules
has PubMed Central identifier	PMC7168432
has PubMed identifier	15170592
schema:publication	Med Res Rev
resource representing a document's body	covid:11650b1552206bab37e5a751670a94aa3c38137c#body_text
is schema:about of	named entity 'effective' named entity 'VALIDATED' named entity 'URGENT' named entity 'ABOUT' named entity 'EVENTS' »more»

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