About: Neurostimulation and Reach-to-Grasp Function Recovery Following Acquired Brain Injury: Insight From Pre-clinical Rodent Models and Human Applications

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About: Neurostimulation and Reach-to-Grasp Function Recovery Following Acquired Brain Injury: Insight From Pre-clinical Rodent Models and Human Applications Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Neurostimulation and Reach-to-Grasp Function Recovery Following Acquired Brain Injury: Insight From Pre-clinical Rodent Models and Human Applications
Creator	Barany, Deborah Karumbaiah, Lohitash Latchoumane, Charles-Francois Singh, Tarkeshwar De Marchis, Cristiano »more»
topic	covid:0e7cce260ff06b189a048433902098d301e7fd07#this
source	PMC
abstract	Reach-to-grasp is an evolutionarily conserved motor function that is adversely impacted following stroke and traumatic brain injury (TBI). Non-invasive brain stimulation (NIBS) methods, such as transcranial magnetic stimulation and transcranial direct current stimulation, are promising tools that could enhance functional recovery of reach-to-grasp post-brain injury. Though the rodent literature provides a causal understanding of post-injury recovery mechanisms, it has had a limited impact on NIBS protocols in human research. The high degree of homology in reach-to-grasp circuitry between humans and rodents further implies that the application of NIBS to brain injury could be better informed by findings from pre-clinical rodent models and neurorehabilitation research. Here, we provide an overview of the advantages and limitations of using rodent models to advance our current understanding of human reach-to-grasp function, cortical circuitry, and reorganization. We propose that a cross-species comparison of reach-to-grasp recovery could provide a mechanistic framework for clinically efficacious NIBS treatments that could elicit better functional outcomes for patients.
has issue date	2020-07-21(xsd:dateTime)
bibo:doi	10.3389/fneur.2020.00835
has license	cc-by
sha1sum (hex)	0e7cce260ff06b189a048433902098d301e7fd07
schema:url	https://doi.org/10.3389/fneur.2020.00835
resource representing a document's title	Neurostimulation and Reach-to-Grasp Function Recovery Following Acquired Brain Injury: Insight From Pre-clinical Rodent Models and Human Applications
has PubMed Central identifier	PMC7396659
schema:publication	Front Neurol
resource representing a document's body	covid:0e7cce260ff06b189a048433902098d301e7fd07#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/0e7cce260ff06b189a048433902098d301e7fd07
is schema:about of	named entity 'application' named entity 'rodent' named entity 'impact' named entity 'informed' named entity 'Neurostimulation' »more»

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