About: Coronavirus envelope protein: current knowledge

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Coronavirus envelope protein: current knowledge
Creator	Fielding, Burtram Schoeman, Dewald
source	Medline; PMC; WHO
abstract	BACKGROUND: Coronaviruses (CoVs) primarily cause enzootic infections in birds and mammals but, in the last few decades, have shown to be capable of infecting humans as well. The outbreak of severe acute respiratory syndrome (SARS) in 2003 and, more recently, Middle-East respiratory syndrome (MERS) has demonstrated the lethality of CoVs when they cross the species barrier and infect humans. A renewed interest in coronaviral research has led to the discovery of several novel human CoVs and since then much progress has been made in understanding the CoV life cycle. The CoV envelope (E) protein is a small, integral membrane protein involved in several aspects of the virus’ life cycle, such as assembly, budding, envelope formation, and pathogenesis. Recent studies have expanded on its structural motifs and topology, its functions as an ion-channelling viroporin, and its interactions with both other CoV proteins and host cell proteins. MAIN BODY: This review aims to establish the current knowledge on CoV E by highlighting the recent progress that has been made and comparing it to previous knowledge. It also compares E to other viral proteins of a similar nature to speculate the relevance of these new findings. Good progress has been made but much still remains unknown and this review has identified some gaps in the current knowledge and made suggestions for consideration in future research. CONCLUSIONS: The most progress has been made on SARS-CoV E, highlighting specific structural requirements for its functions in the CoV life cycle as well as mechanisms behind its pathogenesis. Data shows that E is involved in critical aspects of the viral life cycle and that CoVs lacking E make promising vaccine candidates. The high mortality rate of certain CoVs, along with their ease of transmission, underpins the need for more research into CoV molecular biology which can aid in the production of effective anti-coronaviral agents for both human CoVs and enzootic CoVs.
has issue date	2019-05-27(xsd:dateTime)
bibo:doi	10.1186/s12985-019-1182-0
bibo:pmid	31133031
has license	cc-by
sha1sum (hex)	0cf9f507a18a00de76b8bb61a2c5c2b66680dd50
schema:url	https://doi.org/10.1186/s12985-019-1182-0
resource representing a document's title	Coronavirus envelope protein: current knowledge
has PubMed Central identifier	PMC6537279
has PubMed identifier	31133031
schema:publication	Virol J
resource representing a document's body	covid:0cf9f507a18a00de76b8bb61a2c5c2b66680dd50#body_text
is schema:about of	named entity 'birds' named entity 'Recent' named entity 'life cycle' named entity 'integral membrane protein' named entity 'human' »more»

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