About: First 12 patients with coronavirus disease 2019 (COVID-19) in the United States

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	First 12 patients with coronavirus disease 2019 (COVID-19) in the United States
source	MedRxiv
abstract	Introduction: More than 93,000 cases of coronavirus disease (COVID-19) have been reported worldwide. We describe the epidemiology, clinical course, and virologic characteristics of the first 12 U.S. patients with COVID-19. Methods: We collected demographic, exposure, and clinical information from 12 patients confirmed by CDC during January 20-February 5, 2020 to have COVID-19. Respiratory, stool, serum, and urine specimens were submitted for SARS-CoV-2 rRT-PCR testing, virus culture, and whole genome sequencing. Results: Among the 12 patients, median age was 53 years (range: 21-68); 8 were male, 10 had traveled to China, and two were contacts of patients in this series. Commonly reported signs and symptoms at illness onset were fever (n=7) and cough (n=8). Seven patients were hospitalized with radiographic evidence of pneumonia and demonstrated clinical or laboratory signs of worsening during the second week of illness. Three were treated with the investigational antiviral remdesivir. All patients had SARS-CoV-2 RNA detected in respiratory specimens, typically for 2-3 weeks after illness onset, with lowest rRT-PCR Ct values often detected in the first week. SARS-CoV-2 RNA was detected after reported symptom resolution in seven patients. SARS-CoV-2 was cultured from respiratory specimens, and SARS-CoV-2 RNA was detected in stool from 7/10 patients. Conclusions: In 12 patients with mild to moderately severe illness, SARS-CoV-2 RNA and viable virus were detected early, and prolonged RNA detection suggests the window for diagnosis is long. Hospitalized patients showed signs of worsening in the second week after illness onset.
has issue date	2020-03-12(xsd:dateTime)
bibo:doi	10.1101/2020.03.09.20032896
has license	medrxiv
sha1sum (hex)	0be7d6f4eff3d1c2568753f229b2b000763d5bd4
schema:url	https://doi.org/10.1101/2020.03.09.20032896
resource representing a document's title	First 12 patients with coronavirus disease 2019 (COVID-19) in the United States
resource representing a document's body	covid:0be7d6f4eff3d1c2568753f229b2b000763d5bd4#body_text
is schema:about of	named entity 'U.S.' named entity 'WORLDWIDE' named entity 'VIROLOGIC' named entity 'MORE THAN' named entity 'cases' »more»

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