About: Rodent and Germplasm Trafficking: Risks of Microbial Contamination in a High-Tech Biomedical World

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Rodent and Germplasm Trafficking: Risks of Microbial Contamination in a High-Tech Biomedical World
Creator	Schmidt, Jörg Bauer, Beth Mahabir, Esther
source	PMC
abstract	High-tech biomedical advances have led to increases both in the number of mice used for research and in exchanges of mice and/or their tissues between institutions. The latter are associated with the risk of dissemination of infectious agents. Because of the lack of international standardization of health surveillance programs, health certificates for imported rodents may be informative but may not address the needs of the importing facility. Preservation of mouse germ-plasm is achieved by cryopreservation of spermatozoa, embryos, or ovaries, and embryonic stem cells are used for the production of genetically engineered mice. After embryo transfer, recipients and rederived pups that test negative in microbiological screening for relevant microorganisms are released into full barrier holding areas. However, current research shows that embryos may also transmit microorganisms, especially viruses, to the recipient mice. In this article, we discuss regulations and practical issues in the shipping of live mice and mouse tissues, including spermatozoa, embryos, ovaries, and embryonic stem cells, and review work on microbial contamination of these biological materials. In addition, we present ways to reduce the risk of transmission of pathogens to mice under routine conditions.
has issue date	2008-01-01(xsd:dateTime)
bibo:doi	10.1093/ilar.49.3.347
bibo:pmid	18506068
has license	no-cc
sha1sum (hex)	0b37d6c3950e8c9e9bf93a79772a765c47b07c1f
schema:url	https://doi.org/10.1093/ilar.49.3.347
resource representing a document's title	Rodent and Germplasm Trafficking: Risks of Microbial Contamination in a High-Tech Biomedical World
has PubMed Central identifier	PMC7108542
has PubMed identifier	18506068
schema:publication	ILAR J
resource representing a document's body	covid:0b37d6c3950e8c9e9bf93a79772a765c47b07c1f#body_text
is schema:about of	named entity 'MICROBIAL CONTAMINATION' named entity 'ovaries' named entity 'transmission' named entity 'informative' named entity 'MICROBIOLOGICAL' »more»

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