About: Expression profile of genes involved in pathogenesis of pediatric Crohn's disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Expression profile of genes involved in pathogenesis of pediatric Crohn's disease
Creator	Bishop, Ruth Kirkwood, Carl Wagner, Josef Cameron, Donald Catto-Smith, Anthony »more»
source	Medline; PMC
abstract	Background and Aim: Expression profiling of genes specific to pediatric Crohn's Disease (CD) patients was performed to elucidate the molecular mechanisms underlying disease cause and pathogenesis at disease onset. Methods: We used suppressive subtractive hybridization (SSH) and differential screening analysis to profile the mRNA expression patterns of children with CD and age‐ and sex‐matched controls without inflammatory bowel disease (IBD). Results: Sequence analysis of 1000 clones enriched by SSH identified 75 functionally annotated human genes, represented by 430 clones. The 75 genes have potential involvement in gene networks, such as antigen presentation, inflammation, infection mechanism, connective tissue development, cell cycle and cancer. Twenty‐eight genes were previously described in association with CD, while 47 were new genes not previously reported in the context of IBD. Additionally, 29 of the 75 genes have been previously implicated in bacterial and viral infections. Quantitative real‐time reverse transcription polymerase chain reaction performed on ileal‐derived RNA from 13 CD and nine non‐IBD patients confirmed the upregulation of extracellular matrix gene MMP2 (P = 0.001), and cell proliferation gene REG1A (P = 0.063) in our pediatric CD cohort. Conclusion: The retrieval of 28 genes previously reported in association with adult CD emphasizes the importance of these genes in the pediatric setting. The observed upregulation of REG1A and MMP2, and their known impact on cell proliferation and extracellular matrix remodeling, agrees with the clinical behavior of the disease. Moreover, the expressions of bacterial‐ and virus‐related genes in our CD‐patient tissues support the concept that microbial agents are important in the etiopathogenesis of CD.
has issue date	2012-05-24(xsd:dateTime)
bibo:doi	10.1111/j.1440-1746.2011.06973.x
bibo:pmid	22098497
has license	no-cc
sha1sum (hex)	09461361d3f3f756b5c49eb5f1ec3de748ca0a0f
schema:url	https://doi.org/10.1111/j.1440-1746.2011.06973.x
resource representing a document's title	Expression profile of genes involved in pathogenesis of pediatric Crohn's disease
has PubMed Central identifier	PMC7167032
has PubMed identifier	22098497
schema:publication	J Gastroenterol Hepatol
resource representing a document's body	covid:09461361d3f3f756b5c49eb5f1ec3de748ca0a0f#body_text
is schema:about of	named entity 'tissues' named entity 'inflammation' named entity 'upregulation' named entity 'CD.' named entity 'networks' »more»

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