About: A shifty stop for a hairy tail

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A shifty stop for a hairy tail
Creator	Cingolani, Gino Olia, Adam
source	Medline; PMC
abstract	The tail apparatus of the bacteriophage SPP1 is an extraordinary ~1600-Å-long molecular machine. The tail mediates attachment of the virus to the host surface receptor, as well-as ejection of the viral genome into the host. The distal tip of the tail binds the extracellular ectodomain of the Bacillus subtilis receptor YueB, while the tail tube provides a conduit to funnel the viral genome into the host. This process, which culminates with the ejection of the ~44 kb of viral DNA across the thick, cell envelope of the Gram-positive bacterial cell, takes place in a time scale of seconds to minutes and represents a remarkable example of biotransformation. In this issue of Molecular Microbiology, Auzat et al. provide compelling evidence that the two major structural proteins of the SPP1 tail, gp17.1 (~19.1 kDa) and gp17.1* (~28 kDa), share a common N-terminal sequence, and that gp17.1* is generated by a translational frameshift in the gene 17.1. The extra domain fused to gp17.1* is synthesized by a +1 programmed translational frame-shift at the end of gene 17.1, which leads to the synthesis of approximately one gp17.1* for every three equivalents of gp17.1. This finding extends our current knowledge of translational frameshifts and provides a framework to understand how Siphoviridae phages like SPP1 have developed long-tail machines using only two major structural proteins.
has issue date	2008-11-01(xsd:dateTime)
bibo:doi	10.1111/j.1365-2958.2008.06434.x
bibo:pmid	18826406
has license	green-oa
sha1sum (hex)	0896ceda205c251524a97c8687cc7a517a2aa68d
schema:url	https://doi.org/10.1111/j.1365-2958.2008.06434.x
resource representing a document's title	A shifty stop for a hairy tail
has PubMed Central identifier	PMC2779026
has PubMed identifier	18826406
schema:publication	Molecular Microbiology
resource representing a document's body	covid:0896ceda205c251524a97c8687cc7a517a2aa68d#body_text
is schema:about of	named entity 'machines' named entity 'receptor' named entity 'hairy' named entity 'SYNTHESIS' named entity 'EQUIVALENTS' »more»

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