About: The application of self-assembled nanostructures in peptide-based subunit vaccine development

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The application of self-assembled nanostructures in peptide-based subunit vaccine development
Creator	Chandrudu, Saranya Skwarczynski, Mariusz Toth, Istvan Zhao, Guangzu
source	Elsevier; Medline; PMC
abstract	Abstract Peptide based-vaccines are becoming one of the most widely investigated prophylactic and therapeutic health care interventions against a variety of diseases, including cancer. However, the lack of a safe and highly efficient adjuvant (immune stimulant) is regarded as the biggest obstacle to vaccine development. The incorporation of a peptide antigen in a nanostructure-based delivery system was recently shown to overcome this obstacle. Nanostructures are often formed from antigens conjugated to molecules such as polymers, lipids, and peptide, with the help of self-assembly phenomenon. This review describes the application of self-assembly process for the production of peptide-based vaccine candidates and the ability of these nanostructures to stimulate humoral and cellular immune responses.
has issue date	2017-08-31(xsd:dateTime)
bibo:doi	10.1016/j.eurpolymj.2017.02.014
bibo:pmid	32226094
has license	els-covid
sha1sum (hex)	0806026a204dcf0cc37e859f2e8dd27518c56f90
schema:url	https://doi.org/10.1016/j.eurpolymj.2017.02.014
resource representing a document's title	The application of self-assembled nanostructures in peptide-based subunit vaccine development
has PubMed Central identifier	PMC7094324
has PubMed identifier	32226094
schema:publication	European Polymer Journal
resource representing a document's body	covid:0806026a204dcf0cc37e859f2e8dd27518c56f90#body_text
is schema:about of	named entity 'REVIEW' named entity 'MOLECULES' named entity 'OBSTACLE' named entity 'SELF-ASSEMBLY' named entity 'HELP' »more»

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