About: POXVIRUS TROPISM

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	POXVIRUS TROPISM
Creator	Mcfadden, Grant
source	Medline; PMC
abstract	Despite the success of the WHO-led smallpox eradication programme a quarter of a century ago, there remains considerable fear that variola virus, or other related pathogenic poxviruses such as monkeypox, could re-emerge and spread disease in the human population. Even today, we are still mostly ignorant about why most poxvirus infections of vertebrate hosts show strict species specificity, or how zoonotic poxvirus infections occur when poxviruses occasionally leap into novel host species. Poxvirus tropism at the cellular level seems to be regulated by intracellular events downstream of virus binding and entry, rather than at the level of specific host receptors as is the case for many other viruses. This review summarizes our current understanding of poxvirus tropism and host range, and discusses the prospects of exploiting host-restricted poxvirus vectors for vaccines, gene therapy or tissue-targeted oncolytic viral therapies for the treatment of human cancers.
has issue date	2005-03-01(xsd:dateTime)
bibo:doi	10.1038/nrmicro1099
bibo:pmid	15738948
has license	green-oa
sha1sum (hex)	07148c1b730510d2b7306f922bb5a6f96bc54232
schema:url	https://doi.org/10.1038/nrmicro1099
resource representing a document's title	POXVIRUS TROPISM
has PubMed Central identifier	PMC4382915
has PubMed identifier	15738948
schema:publication	Nature Reviews Microbiology
resource representing a document's body	covid:07148c1b730510d2b7306f922bb5a6f96bc54232#body_text
is schema:about of	named entity 'VECTORS' named entity 'HOSTS' named entity 'HOW' named entity 'HOST RANGE' named entity 'VERTEBRATE' »more»

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