About: The Emergence of Human Coronavirus EMC: How Scared Should We Be?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Emergence of Human Coronavirus EMC: How Scared Should We Be?
Creator	Poon, Leo Chan, Renee
source	Medline; PMC
abstract	A novel betacoronavirus, human coronavirus (HCoV-EMC), has recently been detected in humans with severe respiratory disease. Further characterization of HCoV-EMC suggests that this virus is different from severe acute respiratory syndrome coronavirus (SARS-CoV) because it is able to replicate in multiple mammalian cell lines and it does not use angiotensin-converting enzyme 2 as a receptor to achieve infection. Additional research is urgently needed to better understand the pathogenicity and tissue tropism of this virus in humans. In their recent study published in mBio, Kindler et al. shed some light on these important topics (E. Kindler, H. R. Jónsdóttir, M. Muth, O. J. Hamming, R. Hartmann, R. Rodriguez, R. Geffers, R. A. Fouchier, C. Drosten, M. A. Müller, R. Dijkman, and V. Thiel, mBio 4[1]:e00611-12, 2013). These authors report the use of differentiated pseudostratified human primary airway epithelial cells, an in vitro model with high physiological relevance to the human airway epithelium, to characterize the cellular tropism of HCoV-EMC. More importantly, the authors demonstrate the potential use of type I and type III interferons (IFNs) to control viral infection.
has issue date	2013-04-09(xsd:dateTime)
bibo:doi	10.1128/mbio.00191-13
bibo:pmid	23572553
has license	cc-by-nc-sa
sha1sum (hex)	05cf81cc55f7a6f80902a671cac49d85af9782ed
schema:url	https://doi.org/10.1128/mbio.00191-13
resource representing a document's title	The Emergence of Human Coronavirus EMC: How Scared Should We Be?
has PubMed Central identifier	PMC3622931
has PubMed identifier	23572553
schema:publication	mBio
resource representing a document's body	covid:05cf81cc55f7a6f80902a671cac49d85af9782ed#body_text
is schema:about of	named entity '2013' named entity 'multiple' named entity 'cellular' named entity 'type III interferons' named entity 'light' »more»

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