About: Bacterial and viral co-infections complicating severe influenza: Incidence and impact among 507 U.S. patients, 2013

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About: Bacterial and viral co-infections complicating severe influenza: Incidence and impact among 507 U.S. patients, 2013–14 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Bacterial and viral co-infections complicating severe influenza: Incidence and impact among 507 U.S. patients, 2013–14
Creator	Abbas, Zainab Chakrabarti, Anindita Chaparro-Rojas, Fredy Cobb, Sandra Doblecki-Lewis, Susanne »more»
topic	covid:01b9cff3de8b775f53a16d643be1759374faa4df#this
source	Elsevier; Medline; PMC
abstract	BACKGROUND: Influenza acts synergistically with bacterial co-pathogens. Few studies have described co-infection in a large cohort with severe influenza infection. OBJECTIVES: To describe the spectrum and clinical impact of co-infections. STUDY DESIGN: Retrospective cohort study of patients with severe influenza infection from September 2013 through April 2014 in intensive care units at 33 U.S. hospitals comparing characteristics of cases with and without co-infection in bivariable and multivariable analysis. RESULTS: Of 507 adult and pediatric patients, 114 (22.5%) developed bacterial co-infection and 23 (4.5%) developed viral co-infection. Staphylococcus aureus was the most common cause of co-infection, isolated in 47 (9.3%) patients. Characteristics independently associated with the development of bacterial co-infection of adult patients in a logistic regression model included the absence of cardiovascular disease (OR 0.41 [0.23–0.73], p = 0.003), leukocytosis (>11 K/μl, OR 3.7 [2.2–6.2], p < 0.001; reference: normal WBC 3.5–11 K/μl) at ICU admission and a higher ICU admission SOFA score (for each increase by 1 in SOFA score, OR 1.1 [1.0–1.2], p = 0.001). Bacterial co-infections (OR 2.2 [1.4–3.6], p = 0.001) and viral co-infections (OR 3.1 [1.3–7.4], p = 0.010) were both associated with death in bivariable analysis. Patients with a bacterial co-infection had a longer hospital stay, a longer ICU stay and were likely to have had a greater delay in the initiation of antiviral administration than patients without co-infection (p < 0.05) in bivariable analysis. CONCLUSIONS: Bacterial co-infections were common, resulted in delay of antiviral therapy and were associated with increased resource allocation and higher mortality.
has issue date	2016-04-14(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2016.04.008
bibo:pmid	27130980
has license	no-cc
sha1sum (hex)	01b9cff3de8b775f53a16d643be1759374faa4df
schema:url	https://doi.org/10.1016/j.jcv.2016.04.008
resource representing a document's title	Bacterial and viral co-infections complicating severe influenza: Incidence and impact among 507 U.S. patients, 2013–14
has PubMed Central identifier	PMC7185824
has PubMed identifier	27130980
schema:publication	J Clin Virol
resource representing a document's body	covid:01b9cff3de8b775f53a16d643be1759374faa4df#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/01b9cff3de8b775f53a16d643be1759374faa4df
is schema:about of	named entity 'CO-INFECTION' named entity 'CASES' named entity 'APRIL' named entity 'COINFECTION' named entity 'SPECTRUM' »more»

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