About: Impact of RNA Virus Evolution on Quasispecies Formation and Virulence

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Impact of RNA Virus Evolution on Quasispecies Formation and Virulence Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Impact of RNA Virus Evolution on Quasispecies Formation and Virulence
Creator	Masomian, Malihe Mandary, Madiiha Poh, Chit
source	Medline; PMC
abstract	RNA viruses are known to replicate by low fidelity polymerases and have high mutation rates whereby the resulting virus population tends to exist as a distribution of mutants. In this review, we aim to explore how genetic events such as spontaneous mutations could alter the genomic organization of RNA viruses in such a way that they impact virus replications and plaque morphology. The phenomenon of quasispecies within a viral population is also discussed to reflect virulence and its implications for RNA viruses. An understanding of how such events occur will provide further evidence about whether there are molecular determinants for plaque morphology of RNA viruses or whether different plaque phenotypes arise due to the presence of quasispecies within a population. Ultimately this review gives an insight into whether the intrinsically high error rates due to the low fidelity of RNA polymerases is responsible for the variation in plaque morphology and diversity in virulence. This can be a useful tool in characterizing mechanisms that facilitate virus adaptation and evolution.
has issue date	2019-09-19(xsd:dateTime)
bibo:doi	10.3390/ijms20184657
bibo:pmid	31546962
has license	cc-by
sha1sum (hex)	01880ef487dfed3681dd6d296a0a82417b8f38a0
schema:url	https://doi.org/10.3390/ijms20184657
resource representing a document's title	Impact of RNA Virus Evolution on Quasispecies Formation and Virulence
has PubMed Central identifier	PMC6770471
has PubMed identifier	31546962
schema:publication	Int J Mol Sci
resource representing a document's body	covid:01880ef487dfed3681dd6d296a0a82417b8f38a0#body_text
is schema:about of	named entity 'morphology' named entity 'population' named entity 'exist' named entity 'population' covid:arg/01880ef487dfed3681dd6d296a0a82417b8f38a0 »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software