About: COVID-19-related coagulopathy – Is transferrin a missing link?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID-19-related coagulopathy – Is transferrin a missing link?
Creator	Bojkova, Denisa Cinatl, Jindrich Michaelis, Martin Mclaughlin, Katie-May Wass, Mark »more»
source	BioRxiv
abstract	SARS-CoV-2 is the causative agent of COVID-19. Severe COVID-19 disease has been associated with disseminated intravascular coagulation and thrombosis, but the mechanisms underlying COVID-19-related coagulopathy remain unknown. Since the risk of severe COVID-19 disease is higher in males than in females and increases with age, we combined proteomics data from SARS-CoV-2-infected cells with human gene expression data from the Genotype-Tissue Expression (GTEx) database to identify gene products involved in coagulation that change with age, differ in their levels between females and males, and are regulated in response to SARS-CoV-2 infection. This resulted in the identification of transferrin as a candidate coagulation promoter, whose levels increases with age and are higher in males than in females and that is increased upon SARS-CoV-2 infection. A systematic investigation of gene products associated with the GO term “blood coagulation” did not reveal further high confidence candidates, which are likely to contribute to COVID-19-related coagulopathy. In conclusion, the role of transferrin should be considered in the course of COVID-19 disease and further examined in ongoing clinic-pathological investigations.
has issue date	2020-06-16(xsd:dateTime)
bibo:doi	10.1101/2020.06.11.147025
has license	biorxiv
sha1sum (hex)	011573d7b3f6b6287461269bd1f376c9c9e182ce
schema:url	https://doi.org/10.1101/2020.06.11.147025
resource representing a document's title	COVID-19-related coagulopathy – Is transferrin a missing link?
schema:publication	bioRxiv
resource representing a document's body	covid:011573d7b3f6b6287461269bd1f376c9c9e182ce#body_text
is schema:about of	named entity 'promoter' named entity 'reveal' named entity 'infected' named entity 'disease' named entity 'RELATED' »more»

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