About: Function of the Deubiquitinating Enzyme USP46 in the Nervous System and Its Regulation by WD40-Repeat Proteins

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About: Function of the Deubiquitinating Enzyme USP46 in the Nervous System and Its Regulation by WD40-Repeat Proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Function of the Deubiquitinating Enzyme USP46 in the Nervous System and Its Regulation by WD40-Repeat Proteins
Creator	Hodul, Molly Juo, Peter Dahlberg, Caroline Duarte, Carlos Bramham, Clive »more»
source	PMC
abstract	Posttranslational modification of proteins by ubiquitin regulates synapse development and synaptic transmission. Much progress has been made investigating the role of ubiquitin ligases at the synapse, however very little is known about the deubiquitinating enzymes (DUBs) which remove ubiquitin from target proteins. Although there are far fewer DUBs than ubiquitin ligases encoded by the human genome, it is becoming clear that DUBs have very specific physiological functions, suggesting that DUB activity is tightly regulated in vivo. Many DUBs function as part of larger protein complexes, and multiple regulatory mechanisms exist to control the expression, localization and catalytic activity of DUBs. In this review article, we focus on the role of the DUB USP46 in the nervous system, and illustrate potential mechanisms of regulating DUBs by describing how USP46 is regulated by two WD40-repeat (WDR) proteins, WDR48/UAF1 and WDR20, based on recent structural studies and genetic analyses in vivo.
has issue date	2017-12-14(xsd:dateTime)
bibo:doi	10.3389/fnsyn.2017.00016
bibo:pmid	29302259
has license	cc-by
sha1sum (hex)	00352a58c8766861effed18a4b079d1683fec2ec
schema:url	https://doi.org/10.3389/fnsyn.2017.00016
resource representing a document's title	Function of the Deubiquitinating Enzyme USP46 in the Nervous System and Its Regulation by WD40-Repeat Proteins
has PubMed Central identifier	PMC5735123
has PubMed identifier	29302259
schema:publication	Front Synaptic Neurosci
resource representing a document's body	covid:00352a58c8766861effed18a4b079d1683fec2ec#body_text
is schema:about of	named entity 'FUNCTION' named entity 'VERY LITTLE' named entity 'ACTIVITY' named entity 'REVIEW' named entity 'DEUBIQUITINATING ENZYME' »more»

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